Upper Mississippi River

September 12-20, 2025

United States

Discover the beauty of the Upper Mississippi on this 8-night autumnal journey aboard American Cruise Lines’ American Serenade.

Autumnal beauty awaits on this eight-night river cruise.

Discover the beauty of the Upper Mississippi on this 8-night autumnal journey aboard American Cruise Lines’ American Serenade. Begin with a complimentary pre-cruise hotel stay in St. Paul, Minnesota, renowned for its dynamic arts scene and picturesque lakes. Embark in Red Wing, a city whose pioneering story lives on in its many galleries and museums, and set sail for La Crosse. Then head to Dubuque, where you can visit the Museum of Art, Iowa’s oldest cultural institution. Explore the many districts of downtown Dubuque including Cable Car Square, the Historic Millwork District, and Historic Old Main District, once a hideaway for notorious gangster Al Capone. Enjoy the serene landscape as head to Davenport before stopping in Hannibal, to visit the boyhood home of Mark Twain and famously known as the setting for many of his writings. Finally, complete your voyage near St. Louis, famous for its soaring arch.

Special airfare of $495 from the lower 48 states.

Price Per Person
$5,545

Tour Operator
GoNext

Activity Level
Low

Contact Us
865-974-2115
gsnow@utfi.org

Book Now

Request Tour Information

We craft authentic experiences for the first-time traveler to the seasoned pro. Let us know what interests you and we'll provide information for trips that fit the bill.